Osteoporosis Delays the Bone Healing after Mandibular Distraction Osteogenesis in Postmenopausal Osteoporosis Model
نویسندگان
چکیده
This study aimed to evaluate the histological, histomorphometric and radiographic features of the bone repair in ovariectomized rats submitted to mandibular distraction osteogenesis. Thirty female Wistar rats were equally divided in ovariectomy and control group and submitted to mandibular distraction osteogenesis. After 7, 14 and 28 days the animals were sacrificed and mandibles were removed and radiographed. Then, the sections were submitted to histological and histomorphometric analysis. Histological analysis of distraction showed a fibrocellular connective tissue region involved by cartilage matrix that was gradually replaced by bone tissue. The complete ossification was observed only in the control group. Histomorphometry showed that the percentage of bone volume/tissue volume was statistically significant in the control group between the days 7 and 28. The radiographic evaluation did not show statistical differences between the groups and periods. In conclusion, osteogenesis induced by mandibular distraction osteogenesis in ovariectomized female rats was slower, suggesting the influence of estrogen in bone repair in the histological and histomorphometric analysis. Experimental article (J Int Dent Med Res 2012; 5: (2), pp. 51-60)
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